The end of the First Tiberium War saw a Nod victory. The ion cannon strike on the White House left GDI with global condemnation, resulting in cut funding and restructuring by the United Nations. With GDI out of the way, Nod was free to pursue their global ambitions.
The worldwide proliferation of Tiberium led to a global environmental disaster, while countries either descend into anarchy or are overthrown by the Brotherhood. The United Nations became overburdened by one humanitarian crisis after another. Exacerbated by Nod agents and provocateurs infiltrating the organization, the United Nations soon collapsed under its own weight. The remnants of GDI were forced to fend themselves from the Brotherhood's onslaught.